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Two-phase vesicles: a study on evolutionary and stationary models

M.M. Sahebifard, A. Shahidi and S. Ziaei-Rad 

European Biophysics Journal, Volume 46, Issue 4, September 2016, Pages 343–350



In the current article, the dynamic evolution of two-phase vesicles is presented as an extension to a previous stationary model and based on an equilibrium of local forces. In the simplified model, ignoring the effects of membrane inertia, a dynamic equilibrium between the membrane bending potential and local fluid friction is considered in each phase. The equilibrium equations at the domain borders are completed by extended introduction of membrane section reactions. We show that in some cases, the results of stationary and evolutionary models are in agreement with each other and also with experimental observations, while in others the two models differ markedly. The value of our approach is that we can account for unresponsive points of uncertainty using our equations with the local velocity of the lipid membranes and calculating the intermediate states (shapes) in the consequent evolutionary, or response, path.



A. Two-phase vesicle; B. Dynamic evolution; C. Membrane elastic force; D. Friction force; E. Membrane section reactions


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